Our Supplement Philosophy

Supplements on TRT should serve specific, evidence-based purposes — not add unnecessary expense or complexity to your protocol. We recommend starting with the basics and adding only what your bloodwork or symptoms suggest you need.

The Core TRT Support Stack

Omega-3 Fish Oil (2–4g EPA/DHA daily)

TRT has positive effects on cardiovascular markers, but supporting heart health with omega-3 fatty acids is prudent for any man on long-term hormone therapy. EPA and DHA reduce inflammation, support endothelial function, and improve lipid profiles. Choose a product with verified EPA/DHA content and third-party testing for heavy metals.

Magnesium (200–400mg daily)

Magnesium is involved in over 300 enzymatic processes, including testosterone production and sleep regulation. Deficiency is common — estimated at 50–80% of the US population. Magnesium glycinate or threonate are the best-absorbed forms. Avoid magnesium oxide, which is poorly absorbed.

Vitamin D3 (2,000–5,000 IU daily, titrated to blood levels)

Vitamin D functions as a hormone precursor and is essential for testosterone production, immune function, and bone health. Test your 25-OH vitamin D level and supplement to maintain 40–60 ng/mL. Many men are deficient, especially those who work indoors.

Zinc (25–50mg daily)

Essential cofactor for testosterone synthesis and mild aromatase modulation. Particularly important if your diet is low in red meat and shellfish. Balance with copper (2mg per 15mg zinc) for long-term use.

Optional Additions

DIM (100–200mg daily)

If your estradiol trends toward the higher end of normal, DIM supports healthy estrogen metabolism. Not necessary for all men on TRT — guided by bloodwork. See our estrogen blocker guide.

CoQ10 (100–200mg daily)

Supports mitochondrial energy production and cardiovascular health. Particularly valuable for men on statins (which deplete CoQ10) or those over 40.

Creatine (3–5g daily)

The most well-studied performance supplement available. Supports muscle strength, recovery, and potentially brain health. Works synergistically with TRT for men who train regularly.

What to Skip

Testosterone boosters: If you're already on TRT, natural T-boosters like ashwagandha and tongkat ali provide minimal additional benefit — you're already getting exogenous testosterone. Save your money.

Excessive antioxidant megadoses: Moderate antioxidant intake is fine. Megadosing vitamins C, E, or other antioxidants has not been shown to improve TRT outcomes and may interfere with exercise adaptation.

Anything promising "amplified testosterone" or "steroid-like gains": Marketing hype. Your TRT dose is what's driving your testosterone levels. No supplement amplifies that effect meaningfully.